Veroudering algemeen

Feltes et al. The developmental aging and origins of health and disease hypotheses explained by different protein networks. Biogerontology, 2011 [Epub ahead of print].

Sköld HN, and Obst M. Potential for clonal animals in longevity and ageing studies. Biogerontology, 2011 [Epub ahead of print].

Carnes A. What is lifespan regulation and why does it exist? Biogerontology, 2011 [Epub ahead of print].

Narasimhan et al. PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism. PLoS Genet, 2011, 7(4): e1001377.

Sánchez-Blanco A, and Kim SK. Variable pathogenicity determines individual lifespan in Caenorhabditis elegans. PLoS Genet, 2011, 7(4): e1002047.

Zhai et al. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet, 2011, 7(4): e1002025.

Truscott RJ. Macromolecular deterioration as the ultimate constraint on human lifespan. Ageing Res Rev, 2011 [Epub ahead of print].

Mouton et al. Lack of metabolic ageing in the long-lived flatworm Schmidtea polychroa. Exp Gerontol, 2011 [Epub ahead of print].

Deelen et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell, 2011 [Epub ahead of print].

Ruhaak et al. Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health. J Proteome Res, 2011, 10(4): 1667-74.

Durieux et al. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell, 2011, 144: 79-91.

Vrije radicalen

Halliwell B. Free radicals and antioxidants – quo vadis? Trends Pharmacol Sci, 2011, 32(3): 125-130.

Levensverlenging

Moskalev A, and Shaposhnikov M. Pharmacological inhibition of NF-kB prolongs lifespan of Drosophila melanogaster. Aging, 2011, 3(4) [Advance online publication].

Calorie restrictie

Rong et al. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proc Natl Acad Sci USA, 2011 [Epub ahead of print].

Petrocellis LD, and Marzo VD. Cell signalling: Why fasting worms age slowly. Nature, 2011, 473: 161–163.

Liao et al. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell, 2011 [Epub ahead of print].

Someya et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell, 2010, 143(5): 802-12.

Neurodegeneratieve ziekten

Berwick DC, and  Harvey K. LRRK2 signaling pathways: the key to unlocking neurodegeneration? Trends in Cell Biology, 2011, 21(5): 257-265.

Li et al. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging, 2011 [Epub ahead of print].

Jin et al. Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci USA, 2011, 108(14): 5819-5824.

Mastroeni et al. Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging, 2011 [Epub ahead of print].

Maltsev et al. The role of β-amyloid peptide in neurodegenerative diseases. Ageing Res Rev, 2011 [Epub ahead of print].

Park et al. Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation. Biochem Biophys Res Commun, 2011, 408(4): 602-8.

Borro et al. One-carbon metabolism alteration affects brain proteome profile in a mouse model of Alzheimer's disease. J Alzheimers Dis, 2010, 22(4): 1257-1268.

Minagawa et al. Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function. J Biol Chem, 2010, 285(49): 38382-8.

 

Cardiovasculaire ziekten

Schunkert et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genet, 2011, 43: 333-338.

Laflamme MA, and Murry CE. Heart regeneration. Nature, 2011, 473: 326–335.

Moore KJ, and Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell, 2011, 145(3): 341-355.

Feig et al. HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. Proc Natl Acad Sci USA, 2011, 108(17): 7166-7171.

Cancer

Xu et al. Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nature Chem Biol, 2011, 7: 285-295.

Progeria

Serio RN. Unraveling the Mysteries of Aging Through a Hutchinson–Gilford Progeria Syndrome Model. Rejuvenation Res, 2011, 14(2): 133-141.

Verouderings-gerelateerde maculaire degeneratie

Wong et al. Prevention of age-related macular degeneration. Int Ophthalmol, 2011, 31(1): 73-82.

Kaneko et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature, 2011, 471: 325–330.

Mitochondria

Innocenti et al. Experimental Evidence Supports a Sex-Specific Selective Sieve in Mitochondrial Genome Evolution. Science, 2011, 332: 845-848.

Stamcellen

Encinas et al. Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell, 2011, 8(5): 566-579.

Norddahl et al. Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging. Cell Stem Cell, 2011, 8(5): 499-510.

Anokye-Danso et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell, 2011, 8: 376-388.